Synthesis-68Ga Core-Doped Iron Oxide Nanoparticles For Dual Positron ET l Protocol Preview

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Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T1)Magnetic Resonance Imaging - a 2 minute Preview of the Experimental Protocol

Irene Fernández-Barahona, Jesús Ruiz-Cabello, Fernando Herranz, Juan Pellico
Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Nanobiotechnology, Molecular Imaging and Metabolomics Lab; Universidad Complutense de Madrid (UCM), CIC biomaGUNE and CIBER de Enfermedades Respiratorias (CIBERES). Ikerbasque, Basque Foundation for Science; CIBER de Enfermedades Respiratorias (CIBERES), Advanced Imaging Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC);

Here, we present a protocol to obtain 68Ga core-doped iron oxide nanoparticles via fast microwave-driven synthesis. The methodology renders PET/(T1)MRI nanoparticles with radiolabeling efficiencies higher than 90% and radiochemical purity of 99% in a 20-min synthesis.

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