Top 5 Antibiotics That Can Trigger C. diff Infections

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Antibiotics are the number one cause of C. diff infections. For many people, it starts with a routine prescription — clindamycin for dental work, Cipro for a UTI, or cephalosporins for a sinus infection. Weeks later, they’re facing relentless diarrhea, relapse fears, and frustration when switching antibiotics or trying Imodium doesn’t work.

The truth is, not all antibiotics carry the same risk. Some are far more likely to trigger C. diff, while others are lower risk. In this video, you’ll learn which ones to watch for, what factors raise the odds of C. diff, and the questions you can ask your doctor to feel more confident about your choices.

In this video you’ll learn:

0:00 Introduction
0:59 Medical disclaimer
1:35 What Is C. diff & Why Antibiotics Trigger It
4:22 Top 5 Antibiotics Most Likely to Cause C. diff
9:49 Lower-Risk Antibiotics
13:46 Course Length & Relapse Risk
15:50 Who’s Most At Risk After Antibiotics
18:45 Key Takeaways & Questions to Ask Your Doctor

► More from Michelle
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C Diff and Gut Symptom FAQs: https://www.c-difficile-treatment.com...
How to choose the best probiotic: https://www.c-difficile-treatment.com...
3 Steps to Stop C. diff: https://www.c-difficile-treatment.com...

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The highest risk of C diff come from the antibiotics clindamycin, cefdinir, cefuroxime, and fluoroquinolones vs doxycycline (Zhang J, Chen L, Gomez-Simmonds A, Yin MT, Freedberg DE. Antimicrob Agents Chemother. 2022;66(12):e01129-22. doi:10.1128/aac.01129-22). PubMed

Comparative risk & duration: 10- and 14-day courses increased risk 12% and 27% vs 7-day; risks differ widely even for similar indications (Brown KA, Langford B, Schwartz KL, et al. Clin Infect Dis. 2021;72(5):836-844. doi:10.1093/cid/ciaa124). PubMed

Lower-risk antibiotics: Doxycycline/minocycline show relatively low CDI promotion in clinical/mechanistic work (Xu D, Liu A, et al. Gut Microbes. 2022;14(1):2066005. doi:10.1080/19490976.2022.2066005). PMC

People who’ve already experienced C. diff face much higher odds of catching it again: Song JH, Chang Y, Kim H, et al. Recurrent Clostridium difficile Infection: Risk Factors, Clinical Characteristics, and Outcomes. PMC. 2018. Available from: https://www.ncbi.nlm.nih.gov/pmc/arti...


► About Michelle
Michelle Moore is a former pharmaceutical microbiologist who battled years of recurring Staph infections and chronic health issues. Like many, she trusted conventional medicine — until it fell short. That turning point sparked a deep search for real, root-cause solutions. Through years of research, trial and error, and learning from holistic and alternative medicine, Michelle finally recovered her health — naturally.

In 2007, she and her husband Les, a pharmaceutical chemist of 17 years, founded Embrace Health to share the tools that helped her heal. Since then, they’ve reached tens of thousands of people worldwide through their best-selling books on MRSA and C. difficile, natural products, and science-based educational resources — helping others find relief, rebuild their health and restore their quality of life.

► Disclaimer
We’re not doctors, and this video and associated content is not medical advice. We’re sharing what we’ve learned through personal experience, scientific research, and nearly two decades of helping others recover naturally. This content is for educational purposes only and isn’t intended to diagnose, treat, cure, or prevent any disease. Always talk to your doctor before starting any new supplement, protocol, or diet — especially if you're on medication or managing a serious health condition. Note: Some links may be affiliate links and we may earn a small commission if you purchase through them, at no extra cost to you.

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