The Future of Epigenetics: How DNA Methylation & Genetics Combine to Transform Health

Описание: In this expert conversation, Dr. Yael Joffe (3X4 Genetics) interviews Ryan Smith of TruDiagnostic to explore the dynamic relationship between inherited DNA and gene expression. Discover how polygenic and methylation risk scores are revolutionizing personalized medicine, and why combining genetic and epigenetic data is essential for accurate, actionable healthcare. Whether you’re a clinician, researcher, or health enthusiast, this discussion breaks down complex science into powerful insights for the future of prevention, aging, and personalized interventions.

Key Talking Points:
• What is epigenetics and why it matters beyond genetics
• How DNA methylation acts as an “off switch” for gene expression
• The critical difference between genetics (hardware) and epigenetics (software)
• Insight vs. action: using both genetic and epigenetic data for better outcomes
• Polygenic risk scores vs. methylation risk scores—how they complement each other
• Why combining data sets improves prediction of disease and response to therapy
• Future applications in aging, healthspan, and personalized interventions
• The clinical value of measuring before-and-after intervention effects using epigenetics