Inside the Study Linking Infant Gut Bacteria to Lower Allergy Risk
Автор: HCPLive
Загружено: 2026-02-04
Просмотров: 4
Описание:
New research published in Nature Microbiology suggests that early-life colonization with specific bifidobacteria may lower the risk of allergic sensitization in childhood.
In this interview, Susanne Brix Pedersen, PhD, professor at the Technical University of Denmark, discusses findings from a longitudinal birth cohort showing that infants with high levels of aromatic lactate–producing bifidobacteria had reduced food allergen–specific IgE and lower rates of atopic dermatitis. The protective effect appears to be mediated by the bacterial metabolite 4-hydroxy-phenyllactate, which selectively inhibited IgE production in human immune cell experiments.
Pedersen also explains how delivery mode, breastfeeding, and early-life exposures influence microbial colonization—and why these findings may inform future preventive strategies for food allergy, eczema, and asthma.
Key Highlights:
00:07: About the study: Primary clinical question, trial design
02:11: Role of aromatic lactate-producing bifidobacteria
03:44: 4-hydroxyphenyl lactate as a mediator
04:34: Strength of the evidence linking early gut colonization to lower food allergy risk
#allergy #foodallergy #atopicdermatitis #gutbacteria #pediatrics
Learn more about the study: https://www.hcplive.com/view/early-li...
More allergy content: https://www.hcplive.com/clinical/allergy
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