How GLP-1 and GIP Receptors Map the Future of Metabolic Therapy |Dr. David Hodson | Celtarys | 177

Описание: What if you could actually see where your GPCR-targeted drug goes—inside the brain or pancreas, in real time?

This episode unpacks how new imaging tools are transforming GLP-1 and GIP receptor research in metabolic disease, with long-tail impact for drug development, validation, and translational success.

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Professor David Hodson is the Robert Turner Professor of Diabetic Medicine at the University of Oxford. Trained as a veterinary surgeon and now leading translational research into metabolic diseases, Hodson bridges the worlds of cellular imaging, pharmacology, and GPCR biology. His lab’s work—particularly on visualizing GLP-1 and GIP receptors in vivo—is reshaping how we approach drug targeting and receptor mapping in complex tissues.

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What You’ll Learn / Key Topics
• How fluorescent tools revealed where GLP-1 drugs actually bind in brain and pancreas
• Why GPCR antibodies still fail—and what replaces them in live imaging
• What surprised Hodson most about drug access and receptor signaling in vivo
• How a “failed” photopharmacology project became a field-shaping breakthrough
• Why drug rebound, lean mass loss, and side effects demand GPCR-based solutions
• What’s next: personalized therapies vs. expanding the GPCR target map

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Timestamps

00:00 | Intro — Dr. GPCR Podcast
01:40 | Prof. David Hodson Joins the Show
02:00 | From Vet School to Metabolic Research
04:20 | Why Physiology & Pharmacology Won Him Over
06:00 | Discovering Neuroendocrinology
08:40 | What Pulled Him into Type 2 Diabetes
10:30 | How GPCRs Shape Metabolic Health
12:50 | GLP-1, GIP & the Rise of Incretin Drugs
16:40 | Peptides as Drugs: Stability, Design & Delivery
18:55 | AI & Structure-Guided GPCR Discovery
20:05 | Cryo-EM + MD: Seeing GPCR Mechanism in Action
21:40 | Collaboration with Celtarys Research Begins
22:20 | Why Interdisciplinary Teams Win in Science
24:30 | The Origin of the JB Collaboration
26:50 | Chemical Tools That Reveal GPCR Biology
28:35 | Visualizing GLP-1R, GIPR & Tissue Localization
30:20 | Brain Penetration, Targeting & Drug Efficacy
32:00 | The GPCR Antibody Crisis
33:20 | Negative Data & Better Validation Standards
36:20 | Human Protein Atlas & GPCR Antibody Rigor
37:40 | The DBP Discovery: Alpha Cells Signal Differently
41:00 | Why Good Data Still Feels Like Magic
42:10 | Future of GPCR Therapies in Metabolic Disease
45:20 | Rebound Weight, Side Effects & Variability
47:00 | GPCRs as Addressable Targets for Drug Delivery
48:45 | Personalized Metabolic Medicine: What’s Possible?
52:15 | Using Human Genetics to Understand GPCR Function
52:28 | Career Advice for New Scientists
55:30 | Thriving Inside & Outside Academia
56:55 | Choosing the Right PI & Research Environment
57:25 | Final Thoughts with David Hodson
58:55 | Outro

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Guest Link
• https://www.birmingham.ac.uk/staff/pr...

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