Nucleophilic substitution Reaction SN || Types of SN || Mechanism || Different between Sn1 and Sn2

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Watch this video till the end to understand SN1 and SN2 nucleophilic substitution reactions in the aliphatic system clearly, with easy explanations and conceptual understanding.
This lecture is perfect for Pharmacy, Medical, Nursing, BS Chemistry, and Allied Health students preparing for exams, viva, or quick revision.

In this video, we discuss Nucleophilic Substitution Reactions in detail, focusing on SN1 (Unimolecular) and SN2 (Bimolecular) mechanisms. These reactions play a major role in Organic Chemistry, especially when studying the behavior of alkyl halides and how nucleophiles replace leaving groups. Understanding these concepts not only helps in theory exams but also in practical interpretation of reaction mechanisms.

First, we explain what a nucleophile is, what is meant by a leaving group, and how substitution reactions occur in aliphatic compounds. Then we move into the detailed mechanism of SN1 reaction, where the formation of a carbocation intermediate is the key step. We discuss how the reaction rate depends only on the substrate, why tertiary halides favor SN1, and how polar protic solvents help stabilize the carbocation. We also highlight that SN1 reactions produce racemization, giving a mixture of stereochemical products.

Next, the SN2 reaction mechanism is described in a simple and visual way. We explain the one-step backside attack, the formation of a transition state, and why primary alkyl halides favor SN2 pathways. You will clearly understand how strong nucleophiles and polar aprotic solvents play an important role in SN2 reactions. The concept of Walden Inversion (inversion of configuration) is also explained with easy-to-remember examples.

Finally, we summarize the difference between SN1 and SN2 reactions in a simple comparison table, which helps in quick revision for exams.

This lecture is made simple to help students grasp mechanisms, rate laws, stereochemical outcomes, and influencing factors quickly and effectively.

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SN1 mechanism, SN2 mechanism, nucleophilic substitution, organic chemistry lecture, carbocation intermediate, backside attack, Walden inversion, reaction rate, polar protic solvent, polar aprotic solvent, tertiary alkyl halide, primary alkyl halide, stereochemistry, pharmacy notes



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