Pathology Central Race in Medicine: SCID, the Navajo Nation and the Jicarilla Apache

Описание: This video will provide context to the statement, " “The overall prevalence of [severe combined immunodeficiency] is approximately 1 in 65,000 to 1 in 100,000, but it is 20 to 30 times more frequent in some Native American populations.” from the 10th edition of Robbins Basic Pathology.

The statement, while factual, feels a bit like a "factoid" to me. Without context, it is just something else to show up on an exam question. I address the origins and migration of the Athabascan peoples, details of the Long Walk of the Navajo, the evolutionary consequences of population bottlenecks and how an understanding of all of this can lead to better patient care.

References (links follow each citation)

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Holve S, Hu D, McCandless SE. Metachromatic leukodystrophy in the Navajo: fallout of the American-Indian wars of the nineteenth century. Am J Med Genet. 2001 Jul 1;101(3):203-8. doi: 10.1002/ajmg.1362. PMID: 11424134. Link: https://pubmed.ncbi.nlm.nih.gov/11424...

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Li L, Drayna D, Hu D, Hayward A, Gahagan S, Pabst H, Cowan MJ. The gene for severe combined immunodeficiency disease in Athabascan-speaking Native Americans is located on chromosome 10p. Am J Hum Genet. 1998 Jan;62(1):136-44. doi: 10.1086/301688. PMID: 9443881; PMCID: PMC1376812. Link: https://pubmed.ncbi.nlm.nih.gov/9443881/

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Murphy S, Hayward A, Troup G, Devor EJ, Coons T. Gene enrichment in an American Indian population: an excess of severe combined immunodeficiency disease. Lancet. 1980 Sep 6;2(8193):502-5. doi: 10.1016/s0140-6736(80)91833-4. PMID: 6105560.Link: https://pubmed.ncbi.nlm.nih.gov/6105560/

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