Ab Development to IND: Early Risk Mitigation, Target Specificity, & mRNA-LNP Delivery
Автор: Charles River Labs
Загружено: 2025-12-01
Просмотров: 29
Описание:
Traditional pathways for antibody IND submission often overlook opportunities to mitigate risks early or accelerate candidate selection. This 30-minute presentation questions that approach by introducing more strategic, early decision points and examining alternative delivery platforms that could shift the development trajectory, especially in oncology.
You’ll learn how to:
• De-risk early with target specificity profiling using the proprietary Retrogenix® Cell Microarray, detecting unexpected off-target binding across thousands of human membrane proteins
• Leverage translationally relevant models for in vitro and in vivo pharmacology, improving predictive power before IND
• Integrate safety screening earlier to reduce late-stage attrition
• Explore a complementary delivery strategy using mRNA-LNP technology, unlocking new possibilities for solid tumor immunotherapy and improving scalability
Whether optimizing lead candidates or exploring novel delivery modalities, this session offers a fresh perspective on building a more agile and future-proof antibody development program.
Click the link below to learn more.
https://bit.ly/4oS2P5s
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