Alexandra Stolzing - Outlook on Anti-aging Projects of SENS in 2021 - Lifespan.io

Описание: In the presentation entitled “Science at SENS” at Lifespan.io’s 2021 EARD conference, Dr. Alexandra Stolzing of SENS Research Foundation presents an overview of internal projects running at SENS as well as external projects that the foundation is funding in partnership with various universities and companies.

Dr. Alexandra Stolzing is a Professor of Biogerontological Engineering at Loughborough University as well as the vice president of research at SENS Research Foundation. Her research in aging includes areas such as regenerative medicine, cell & gene therapy development, and neurodegenerative diseases.

SENS Research Foundation works to develop, promote, and ensure widespread access to therapies that cure and prevent the diseases and disabilities of aging by comprehensively repairing the damage that builds up in our bodies over time.

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Thank you very much for attending today's presentation, and it's all about the science at SENS. I will be giving an overview today about the projects that we have running internally at SENS and about the projects that we're funding externally with partners at universities or companies.

I will be giving a quick overview about the SENS spin-off companies and where they are currently, what they're doing, a brief summary of what education programs we have running, a summary of the grants, and very quickly just talk about future projects and what's coming up in the future.

As it's my duty, this is a slide about the SENS damage categories. Don't be afraid, I will not be going into any sorts of details, I just want you to look at the right side and get a little bit of familiarity with the categories. We use them to see that we have, hopefully, one project for each of the categories.

It's not like it's a must we have to have, but we always try to aim to have one project for each of the categories. Unfortunately, we don't have currently a project for the OncoSENS category. So, if someone is out there and has some great ideas about what we can do, we really would love to hear about it.

Let's talk about the external projects first. The longest-running external project that we actually have is a project that we run with Dr. Jonathan Clark. It is about tissue cross-linking, and his job and his research is about finding tissue cross-links, non-enzymatic cross links, and long-lasting proteins of the extracellular matrix. It's part of the glycoSENS category.

Here is where I use this kind of icons to guide you, which category is this. it has been running over five years; there have been three publications last year, so please look him up. They're also on our website if you want to read them. We always try to keep our literature list up to date so that you can find it easily.

We also have a new, very exciting project. It's about the functional neuron replacement to rejuvenate the neocortex. It is with Prof. Hebert, and it is basically about the idea of using transdifferentiation of microglial cells to neurons.

So he is transplanting microglia cells into mice brains and turns them into neurons in vivo to basically repopulate the neocortex with new functional neurons. He also is, I think, about to be publishing a summary of this. Look out for his new publications; hopefully, they will show this project update.

Also relatively new is a project with Prof Gudkov, and this is about the active retrobiome as an anti-aging treatment.


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