Calcium Channel Blockers - For Nursing Students and Nurses!

Описание: EmpoweRN.com
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Rizalyn Joy Gadugdug
Maria Salvacion Gonzales
Yasmin Hashmi
Artem Shestakov
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Calcium Channel Blockers, as the name suggests, prevents or reduces the opening of these channels. There are different classes of Calcium channel blockers, but almost of all of them acts on the L-type voltage-gated calcium channel. Therefore, blocking or reducing calcium entry into these cells, means inhibiting calcium effects, and thus causes the following reaction:

Vasodilation – by acting on vascular smooth muscle, Calcium channel blockers reduces contraction of the arteries which causes an increase in arterial diameter. This drugs primarily affect arteries, with minimal effects on venous vessels.



Calcium Channel Blockers also have a Negative Inotropic effect – by acting on cardiac muscle, Calcium channel blockers therefore can reduce the force of the contraction in the heart.



Calcium channel blockers also have a Negative Chrono-tropic – effect – by slowing down the conduction of electrical activity within the heart, therefore Calcium channel blockers may affect the rate of the heartbeat.



They also can exhibit a Negative Dromo-tropic effect – by slowing down the conduction of the electrical activity of the heart, thus the conduction of velocity also decreases, particularly at the atrioventricular node. Which can ultimately slow the heart rate.

Therapeutic Use

Calcium Channel Blockers are used to control a variety of medical condition such as high blood pressure, chest pain, and tachyarrhythmia.



As anti-hypertensive drug – The effects of calcium in the heart muscles, is that it causes the muscle to act aggressively, by contracting more forcefully. Calcium also stimulates vascular smooth muscle contraction resulting in narrow blood vessels. This series of events many times can result in high blood pressure. By preventing the entry of calcium into the heart muscle and vascular smooth muscles (particularly in the arteries), the heart muscle contraction will not be too strong and arterial vessels are able to relax and dilate, leading to lower blood pressure.
As anti-anginal drug – The word angina is one that you will hear a lot as a nursing student and nurse. This is a fancy word for “chest pain.”