Fewer Skin Ulcers in Werner Syndrome Patients Treated with Pioglitazone | Aging-US

Описание: Aging-US #published this #trending research paper on December 2, 2024, in Volume 16, Issue 22, entitled “Less frequent skin ulcers among patients with Werner syndrome treated with pioglitazone: findings from the Japanese Werner Syndrome Registry" by researchers from the Department of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan; Center for Preventive Medical Sciences, Chiba University, Chiba, Japan; Clinical Research Center, Chiba University Hospital, Chiba, Japan; Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan; Department of Orthopaedic Surgery, Nara Medical University, Nara, Japan; Department of Dermatology, Sumitomo Hospital, Osaka, Japan; Diabetes and Endocrinology, Saga-Ken Medical Centre Koseikan, Saga, Japan; Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan; Department of Health Development and Medicine, Osaka University Graduate School of Medicine, Osaka, Japan; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan; General Geriatric Medicine, Kawasaki Medical School, Okayama, Japan; Department of Endocrinology and Metabolic Medicine, Nippon Life Hospital, Osaka, Japan Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Orthopaedic Surgery, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Dermatology, Showa General Hospital, Tokyo, Japan; Geriatrics and General Internal Medicine, Meitetsu Hospital, Nagoya, Japan; Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan; Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, International University of Health and Welfare, Narita, Japan; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.
#aging #werner #syndrome #skin #metformin #research #openaccess #openscience #peerreviewed #journalpublication #publishing #meded

DOI - https://doi.org/10.18632/aging.206161

Corresponding author - Masaya Koshizaka - [email protected]

Abstract

Background and Aim: Werner syndrome (WS) is an autosomal recessive, adult-onset, progeroid syndrome caused by WRN mutations. As refractory skin ulcers significantly affect the quality of life of patients with WS, this study identified ulcer risk factors and assessed prevention methods.

Methods: We analyzed the data of 51 patients with WS enrolled in the Japanese Werner Syndrome Registry between 2016 and 2022. A cross-sectional analysis was performed to determine the association with skin ulcers at baseline. Statistical analyses were conducted, including Welch’s and Pearson’s chi-square tests. Age was adjusted using a logistic regression model.

Results: The mean patient age was 48.8±7.6 years, and 66.7% of patients presented with skin ulcers. Univariate analysis showed that patients with skin ulcers were older than those without ulcers. Systolic blood pressure (SBP) was higher in patients with skin ulcers. Patients without skin ulcers received metformin and pioglitazone treatment significantly more often than those with ulcers. Logistic regression analysis adjusted for age showed that higher SBP remained a significant risk factor for skin ulcers. Patients administered pioglitazone had lower ulcer morbidity.

Conclusions: Age and SBP are risk factors for skin ulcers in patients with WS. Moreover, pioglitazone treatment may prevent skin ulcers.

Sign up for free Altmetric alerts about this article -
https://aging.altmetric.com/details/e...

Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to...

Keywords - aging, Werner syndrome, skin ulcer, metformin, pioglitazon, progeroid syndrome

About Aging-US

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Please visit our website at https://www.Aging-US.com​​ and connect with us:

Facebook -   / agingus  
X -   / agingjrnl  
Instagram -   / agingjrnl  
YouTube -    / @aging-us  
LinkedIn -   / aging  
Pinterest -   / agingus  
Spotify - https://open.spotify.com/show/1X4HQQg...

Media Contact
18009220957
[email protected]