MDMA synthesis in 3 steps & how it could help PTSD therapy (educational) | Chemistry & Science

Описание: 🧠 Did you know that MDMA-assisted therapy was recently suggested to be highly effective for people with severe PTSD? In this video, we will break down MDMA's history and discovery, synthetic approaches from the literature - including a kilo-scale process route - and clinical data from a Phase 3 study investigating MDMA's therapeutic benefit.

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Note, some slides spell safrole as saffrole

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00:00 MDMA might have valuable therapeutic potential
00:37 Uncontrolled drug use is dangerous!!!
00:53 History and discovery of MDMA
02:26 Organic synthesis and chemical reactions: Safrole, piperonal, GMP synthesis
05:43 PTSD burden of disease and unmet need
07:08 Clinical trial design and results
09:48 Short-term MDMA safety seems acceptable - still, long-term or regular use is discouraged!
10:53 Outlook on potential FDA approval

Disclaimer - This channel does not provide medical advice!
No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube.


Key references:
Fully Validated, Multi-Kilogram cGMP Synthesis of MDMA (ACS Omega 2022, 7, 900−907)
MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study (Nature Medicine 2021, 27, 1025)
The origin of MDMA (‘Ecstasy’) – separating the facts from the myth (Die Pharmazie 2006, 61, 966)

Some recommended books on organic synthesis:
Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge)
Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis)
Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions)
Nicolaou; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy)
Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life)
Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)