Class 1 antiarrhythmic drugs explained: How they block sodium channels and control cardiac rhythm

Описание: Step into the electrical corridors of the heart and explore how class I antiarrhythmic drugs keep its rhythm steady. This video guides you through the essentials of sodium channel blockers and how they influence cardiac action potentials as class 1A, 1B and 1C drugs.

You’ll learn:
⚡ The three subclasses: Class IA, IB, and IC
💊 Key drugs in each group
🫀 How they alter depolarization and conduction
📊 Clinical uses and major side effects
🎓 High-yield points for exams and pharmacology courses

If you’re studying cardiology, pharmacology, or preparing for board exams, this video gives you a crisp, structured overview to make the topic feel far less thorny.

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Prior knowledge of the ionic basis of cardiac action potentials and how drugs interact with ion channels would help you gain the most from this lecture. These topics are explained in the following videos:
   • Cardiac action potentials: ionic mechanims...  
   • How drugs block ion channels  

0:00 Targetting sodium channels to control heart rhythm
0:33 Before we begin
01:22 Classificaton of antiarrhythmic drugs
02:24 Role of Na channels in cardiac action potentials
05:00 Effects of class 1 drugs on cardiac action potential
06:08 Class 1a drugs and cardiac action potentials
07:22 Class 1c drugs and cardiac action potentials
09:00 Class 1b drugs and cardiac action potentials
10:55 State-dependent block explains class 1b drug effects
13:06 State-dependent block explains differential class effects
14:44 Open channel block by class 1a and 1c antiarrhythmics
16:21 Binding kinetics of class 1 drugs
12:54 Use-dependence
20:58 Drug binding to Na channels in ischaemic tissue
22:40 Summary
24:56 Class 1 antiarrhythmic drug examples
26:20 Thank you for watching

Credits:
"Nile's Blues" Kevin MacLeod (incompetech.com)
Licensed under Creative Commons: By Attribution 4.0 License
http://creativecommons.org/licenses/b...

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