Biochemistry of Nutrient Sensing, Fasting, Cell Repair | Greg Steinberg

Описание: Dive into the science of AMPK, the cellular "fuel gauge" that regulates energy, nutrient use, and health. Join host Nick Jikomes and metabolism expert Dr. Greg Steinberg as they discuss how fasting, exercise, ketogenic diets, and drugs like metformin and Ozempic activate AMPK to enhance fat burning, mitochondrial health, and metabolic flexibility. Learn about its links to mTOR, cancer prevention, and modern diseases like obesity and diabetes. Perfect for biohackers, fitness enthusiasts, and science lovers—subscribe for more mind-bending insights! #AMPK #Metabolism #Fasting #KetoDiet #ExerciseScience

TOPICS DISCUSSED:

Cellular energy basics: ATP/ADP/AMP as energy currencies; AMP kinase activates on low ATP to conserve and redirect resources, like a budget manager.

AMP kinase mechanics: Heterotrimeric enzyme phosphorylating 100+ substrates; localizes dynamically in cytosol, mitochondria, nucleus to integrate signals.

Nutrient detection: Senses fatty acids in fasting/ketogenic states, boosting fat oxidation and mitochondria independent of energy drops.

Fasting/exercise impacts: Elevate AMP kinase for mitophagy, better fuel switching; mimic historical scarcity absent under modern constant feeding.

mTOR relationship: AMP kinase inhibits mTOR to stop growth in low energy states; feedback loop disrupted by abundance, promoting tissue buildup.

Disease links: Low AMP kinase in obesity/diabetes reduces flexibility; activation prevents cancer but may aid tumor survival in therapy.

Drugs/diets: Metformin and GLP-1s like Ozempic activate AMP kinase for glucose control/weight loss; ketogenic diets activate at intermediate levels for fat efficiency.

ABOUT THE GUEST:
Gregory Steinberg, PhD is a Professor of Medicine at McMaster University and co-directs the Centre for Metabolism, Obesity, and Diabetes Research, focusing on cellular energy sensors like AMP kinase.

*Not medical advice.

00:00:00 Intro
05:06:00 Cellular Metabolism Overview
10:06:00 Energy Sensing & Ratios
15:31:00 Regulation & Subunits
20:24:00 Energy Management Role
25:24:00 Modern Diets & Suppression
30:08:00 Fasting Effects
35:20:00 Activation Mechanisms
40:56:00 Mitochondrial Maintenance
45:32:00 Exercise Activation
50:34:00 Low Activity Consequences
53:16:00 Dysfunction in Obesity
56:29:00 Ketogenic Diets & Mimicry
01:01:04:00 mTOR Relationship
01:04:53:00 Nutrient Specificity
01:06:51:00 Role in Cancer
01:09:36:00 Presence in Cells
01:11:31:00 Evolutionary Balance
01:14:17:00 Research Areas
01:16:34:00 Drugs & Takeaways
01:18:50:00 Outro