21. Ankylosing Spondylitis Simplified 🦴🔥 | High-Yield Internal Medicine for USMLE Step 2 CK

Описание: 📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/conceptualmedicine
📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/conceptual_...

Ankylosing Spondylitis Simplified 🦴🔥 | High-Yield Internal Medicine for USMLE Step 2 CK

Ankylosing Spondylitis (AS) is a chronic inflammatory seronegative spondyloarthropathy that primarily affects the axial skeleton, especially the sacroiliac joints and spine, and is frequently tested in USMLE Step 2 CK due to its classic presentation and strong clinical correlations. AS typically presents in young males (Less than 40 years) with gradual-onset inflammatory back pain that improves with activity but worsens with rest, accompanied by morning stiffness more than 30 minutes, reduced spinal mobility, and buttock pain due to sacroiliitis 🧍‍♂️🔥. Extra-articular features include anterior uveitis (painful red eye), aortic root dilation, conduction abnormalities, restrictive lung disease (due to reduced chest expansion), and enthesitis (Achilles tendon, plantar fascia). It is strongly associated with HLA-B27 positivity. Imaging is crucial — X-ray of the pelvis reveals bilateral sacroiliitis, while later stages show syndesmophytes and a “bamboo spine”. Elevated ESR/CRP supports the inflammatory process, while RF and ANA are negative (seronegative). Treatment includes NSAIDs (first-line), TNF-α inhibitors (e.g., etanercept, adalimumab) for resistant cases, and physical therapy to maintain posture and mobility. Recognizing key clinical clues, imaging findings, and differentiating from mechanical back pain or disc disease is essential for scoring high on USMLE Step 2 CK and in real-world clinical decision-making 📚🦴🩺.

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