FBI Research Scholar: Manish Jha, MBBS, Priti Balchandani, PhD, Scott Russo, PhD, James Murrough
Автор: Icahn School of Medicine
Загружено: 2020-05-11
Просмотров: 204
Описание:
Richard and Susan Friedman Research Scholar Awardees:
Manish Jha, MBBS, Assistant Professor, Psychiatry and Neuroscience
Priti Balchandani, PhD, Associate Professor, Diagnostic, Molecular and Interventional Radiology and Neuroscience
Scott Russo, PhD, Professor, Neuroscience, and Psychiatry
James Murrough, MD, Associate Professor, Psychiatry and Neuroscience
TITLE: Using high-field neuroimaging to unlock the therapeutic potential of orexin antagonists for depressed patients with anger and irritability
ABSTRACT: Irritability affects one in two adults with depression, worsens quality of life, and increases risk for suicide. Yet, there are no treatments currently available that specifically target irritability. Preclinical studies have identified the habenula as a key brain region modulating aggression, a common behavioral manifestation of irritability. Hence, we propose to characterize the role of habenula in the neural circuitry of irritability in humans using ultra-high field neuroimaging, and to generate pilot data demonstrating the potential of orexin antagonists as a novel treatment for irritability.
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