Use of EEG as a Biomarker for Diagnosis and Outcomes in Neurodevelopmental Disorders

Описание: This webinar series addresses a wide range of current topics in Fragile X research. Hosted by FRAXA and organized by Michael Tranfaglia, MD and Patricia Cogram, PhD, sessions feature outstanding speakers from universities and the biotech and pharmaceutical industries.

---- Presentation Abstract ----
The clinical presentation and functional outcome of neurodevelopmental disorders, including single gene disorders such as Fragile X syndrome (FXS), are strikingly heterogenous. This heterogeneity in symptom presentation has posed challenges for the early identification of non-genetically defined disorders such as autism spectrum disorder, and undermines development and approval of drug and behavioral-based interventions. As such, research in biomarkers for diagnosis and monitoring outcomes in neurodevelopmental disorders has garnered great interest over the past decade. Here we present our research using electroencephalography (EEG), a non-invasive method for measuring brain activity, across a variety of populations with increased risk for autism spectrum disorder (high-risk infant-siblings, Tuberous Sclerosis Syndrome, Rett Syndrome, and Fragile X syndrome). We will review findings demonstrating EEG as an effective tool in measuring differences in brain activity in children with significant developmental delays and behavioral challenges and discuss the feasibility of EEG’s use as a predictive measure of autism. In the second half of our talk we will focus on using EEG to identify neural markers of language acquisition across various neurodevelopmental disorders, including preliminary results from an EEG study in young children with Fragile X syndrome.

---- Speakers ----
Charles A. Nelson III, PhD
Professor, Harvard Medical School

Carol Wilkinson, MD, PhD
Instructor, Boston Children's Hospital

---- Timestamps ----
0:00 Intro with Dr. Michael Tranfaglia
2:20 EEG Biomarkers of Autism Risk
29:00 EEG Biomarkers in Children with Fragile X Syndrome
1:01:29 Questions and Answers
1:27:31 Closing remarks

---- About FRAXA ----

FRAXA’s mission is to find effective treatments and ultimately a cure for Fragile X syndrome. We directly fund research grants and fellowships at top universities around the world. We partner with biomedical and pharmaceutical companies, large and small, to bridge the gap between research discoveries and actual treatments.

Treatments for Fragile X are likely to help people affected by autism, Alzheimer’s, and other brain disorders.

To learn more about FRAXA's Fragile X syndrome research, to get involved with Fragile X awareness and events or to donate to FRAXA research, visit www.fraxa.org

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