The current standard of care for GvHD prophylaxis in older patients undergoing transplantation
Автор: VJHemOnc – Video Journal of Hematology & HemOnc
Загружено: 2026-03-10
Просмотров: 15
Описание:
Sameem Abedin, MD, Medical College of Wisconsin, Milwaukee, WI, discusses the standard of care (SoC) for graft-versus-host disease (GvHD) prophylaxis in older patients undergoing reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (SCT). The current SoC regimen combines post-transplant cyclophosphamide (PTCy) at a dose of 50 mg/kg on days +3 and +4 with a calcineurin inhibitor (CNI) and mycophenolate mofetil (MMF), and reduces the incidence of clinically significant acute and chronic GvHD compared to CNI-based prophylaxis alone. Dr Abedin also mentions alternative approaches being explored, including adding a JAK inhibitor, such as ruxolitinib, to CNI-based prophylaxis. This interview took place virtually.
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