Cholinergic Receptors: Nicotinic versus Muscarinic | Pharmacology Explained

Описание: Cholinergic receptors are central to autonomic physiology, neuromuscular transmission, and central nervous system function. In this lecture, we explore the two major receptor families that mediate the actions of acetylcholine: nicotinic and muscarinic receptors.
Beginning with their historical discovery and early pharmacological characterisation, the video explains how these receptors differ in structure, signalling mechanisms, and physiological roles. We examine ligand-gated ion channels versus G protein-coupled receptors, receptor subunit diversity, subtype classification, and the pharmacological principles that distinguish agonists and antagonists.
Clinical examples are used throughout to illustrate how receptor structure and distribution guide therapeutic application, including bronchodilators, treatments for bradycardia, motion sickness, overactive bladder, and nicotine dependence.
The lecture concludes by highlighting how receptor localisation, desensitisation, and regulation shape both physiological responses and drug effects.
This video is designed for undergraduate and early postgraduate students in pharmacology, medicine, biomedical science, and related disciplines.

00:03 -The birth of cholinergic signalling
03:09 -Electrophysiology splits the families
05:21 -Anatomical distribution predicts receptor type
07:08 -Molecular identification
09:27 -Nicotinic receptors
14:13 -Muscarinic receptors
17:37 -Cholinergic receptor agonists
21:24 -Nicotinic receptor antagonists
26:36 -Muscarinic receptor antagonists
33:22 -Cholinergic receptors as dynamic proteins
35:53 -Cholinergic Receptors: Principles and Perspectives

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