Why the Membrane Becomes Un-Responsive || Absolute & Relative Refractory Period

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Refractory Period: Absolute & Relative Refractory Period
From initiation of action potential to just before repolarization is complete, no stimulus can generate a second action potential. This is called absolute refractory period. The reason for this is that the sodium channels are in inactive configuration, which cannot be opened. And they recover only after repolarization. During hyperpolarized state, a second action potential can be generated but it requires stimulus that is stronger than usual. The reason is, that the membrane is in hyperpolarized state due to continued potassium efflux, and, not all the sodium channels have recovered yet. So it requires stronger stimulus to recruit enough channels and generate action potential.

Chapters:
00:00 Intro
00:04 States of Sodium Channel During Action Potential
01:55 Refractory Period
02:13 Absolute Refractory Period
03:02 Relative Refractory Period
04:00 Summary

Dr Vipul Navadiya

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