Analytical Characterization Techniques for Nanoparticle mRNA Therapeutics

Описание: Presented By: Nagarjun Kasaraneni, PhD

Speaker Biography: Nagarjun is a Scientist in Technical Operations at Sana Biotechnology (Cambridge, MA). He completed his PhD in Medical Sciences at Texas A&M University (Texas), where he worked on development of a universal lentiviral vector platform for different gene therapy applications. After his graduate school, he joined Lonza (Houston), as a research intern and worked on developing cell lines for high titer productivity of different viral vectors. Nagarjun currently works on analytical method development to develop fit for purpose genomic assays to characterize viral vectors across Sana gene therapy platforms.

Webinar: Analytical Characterization Techniques for Nanoparticle mRNA Therapeutics

Webinar Abstract: Nanoparticle mRNA Therapeutics has been the focus of intense research driven by the safety profile and several clinical breakthroughs. As of March 2024, there are two mRNA vaccines approved and many are in active clinical trials. The expected increase in demand for specific Nanoparticle mRNA therapeutics still poses many challenges. The current talk tries to summarize the key aspects related to Research and development needs and Chemistry, Manufacturing and Control (CMC) efforts to help this growing demand. We will primarily discuss applying the different orthogonal methods to identify, monitor and control Critical Quality Attributes (CQAs) during the process development and manufacturing process.

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