A Conversation with a Cardiologist: Cardiac Health and Risk in MPNs

Описание: MPN Advocacy & Education International spoke with Dr. Orly Leiva, a fellow at the University of Chicago Medicine, to discuss cardiac complications facing MPN patients. He also answered numerous questions from the viewers.

TIMESTAMPS
00:00 A Conversation with a Cardiologist: Cardiac Health and Risk in MPNs
23:42 In any of the studies in MPN patients, was there any separation between men and women?
24:29 Should I be concerned if I am a female with a hematocrit of 44 and had atherosclerosis on an abdominal ultrasound? When should I go to an ER with chest pain?
26:23 I had rheumatic fever when I was a child which affected my heart. I had a mitral valve repair in 2009. I was diagnosed with ET this past summer. Does this combination increase my risk of heart attack and stroke more than if I had just had ET?
28:00 Is apo-b a test I should ask my hematologist to do?
29:14 Would you recommend an initial cardiac review? Perhaps a stress test, ECK/EKG, peripheral artery test, etc. It seems to me this would be a terrific start to establish a baseline.
33:10 Is there a blood marker or other test that quantifies you with pulmonary hypertension?
34:44 Should I consider statins? I am 72 with ET and currently taking Eliquis. I have a normal lipid profile but calcification in ascending aorta and minimal in coronary arteries.
36:23 Is valvular heart disease more prevalent amongst MPN patients?
37:22 Do MPN medications adversely affect the heart?
39:04 Can one overdo cardio?
39:47 For women do you believe hematocrit should be under 42 or 45?
40:23 I was told A1C is the best test for MPN, and fructosamine is better. What are your thoughts?
41:24 Should all MPN patients have a cardiologist even if they are doing well? Should it be any cardiologist or should I have one specializing in blood disorders?
43:04 I am an ET patient with JAK2 and a known extra heartbeat but with a low heartbeat count. I struggle to get my numbers above 50. I have hypertension and do have a cardiologist. What type of questions should I be asking my medical team?
44:00 I was diagnosed with PV over 24 years ago. For the past 10 years, I have been using Jakafi which has controlled my hemoglobin. My cholesterol profile is unusual as my HDL is low (27) as well as my LDL (83). My LDL particle number is 2176. Are statins appropriate?
45:19 Has cardiovascular risk been stratified according to a patient's mutation (JAK2, MPL, triple negative, etc)?
45:55 How do you know if you have any of the non-thrombotic cardiovascular diseases?
46:43 Should I take 2x per day aspirin together or at separate times during the day?
47:15 Which is better, a cabbage or a stent after a myocardial infarction?
49:14 What time of day is best to take a statin?
49:46 Are there any studies that have insight into any additional complications with your hearts if you have an MPN and an autoimmune disease?
50:11 Can an AV heart block be related to my MPN?
50:57 Is the use of the supplement Nattokinase a useful addition to one's daily regimen to aide in circulation?