What Are The Side Effects Of Duloxetine?

Описание: Video transcript :-
Duloxetine belongs to the drug class of serotonin norepinephrine reuptake inhibitors and is used primarily as an antidepressant medication.
It increases the levels of serotonin and norepinephrine in the synaptic cleft by inhibiting their reuptake in presynaptic neurons.
This enhances neurotransmission, leading to improved mood regulation and modulation of pain pathways.
Major Indications of Duloxetine include Major Depressive Disorder.
Generalized Anxiety Disorder.
Diabetic Peripheral Neuropathy.
Fibromyalgia.
And for managing chronic Musculoskeletal Pain conditions such as osteoarthritis and chronic lower back pain.
It is sometimes used off label for stress urinary incontinence due to its effects on norepinephrine mediated sphincter control.
In this video, our primary goal is to explore the common side effects of duloxetine.
Neurological & Psychiatric Effects include Dizziness, headache, drowsiness, insomnia, anxiety, and fatigue.
Less Commonly, patients may experience seizures, tremors, and serotonin syndrome.
increased risk of suicide.
And discontinuation Syndrome, which is characterized by brain zaps, dizziness, nausea, and mood disturbances upon sudden withdrawal.
Gastrointestinal Effects may include nausea, dry mouth, constipation, diarrhea, and dyspepsia.
Gastrointestinal bleeding and esophagitis may also occur less commonly.
Cardiovascular Effects include tachycardia, palpitations, hypertension.
Less commonly, Orthostatic hypotension and QT prolongation can occur.
Endocrine and metabolic effects include weight changes and hyponatremia.
Other effects include hepatotoxicity and elevated liver enzyme levels.
Excessive sweating.
Urinary retention.
And sexual dysfunction.

#medtoday #medicaleducation #medicalknowledge #medications #healtheducation #healthknowledge #pharmcology #duloxetine #snri #antidepressants