Latest Advancements in Plasma Proteomics: Population-sized Cohort Studies | Dr. Hanno Steen

Описание: In this talk, Dr. Hanno Steen, Harvard Medical School, Boston Children’s Hospital, Massachusetts, USA, talks about how meaningful biomarker studies that account for genetic, environmental, and lifestyle variation require large cohorts – too large for the conventional mass spectrometry-based proteomics platforms.

The Steen Lab aims to analyze thousands of plasma samples to better understand the impact of infection, vaccination, and development on the immune system. These projects motivated us to develop a high-throughput plasma proteomics pipeline that can handle, i.e, process thousands of samples while concomitantly mapping more than a thousand plasma proteins at throughputs of 100 samples per day on a single mass spectrometer. The pipeline, with reagent costs in a range of less than $5 per sample, has been tested and validated in the meantime on more than 10,000 samples from cohorts in various disease and development contexts, showing exquisite robustness. Interestingly, the concepts of this pipeline are widely applicable to a range of other body fluids, even in a sample-sparing environment, such as samples from premature newborns.

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