TP53 in Myeloma: How the p53 Protein Shapes Your Cancer’s Behavior

Описание: Learn why this tiny gene can have a big impact on how myeloma grows and responds to treatment.
Understanding TP53 mutations in multiple myeloma is an important part of knowing your disease and making informed treatment decisions. In this video, we explain what TP53 is, why it matters, how it’s tested, and what it could mean for your prognosis and treatment options. TP53 mutations are included in the new IMWG Definition of High-Risk Cytogenetic Characteristics.

0:00 Intro
0:36 What is TP53, the gene responsible for making tumor protein 53, and where is this gene located?
3:32 What is the difference between a TP53 deletion and a TP53 mutation?
3:59 Why is it important to know the status of the TP53 gene in each allele?
6:626 How is TP53 status determined? How will someone know if the TP53 tumor suppressor gene on each of the two alleles of chromosome 17 is working properly?
7:52 Outro

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