Exploration Science-Ep. 1: Peptide Therapeutics, Manufacturing, and Green Chemistry

Описание: In this episode of Exploration Science, I sat down with Dr. Fernando Albericio, Dr. Beatriz G. de la Torre, and Jonathan Collins at the 2021 TIDES meeting in Boston to discuss their thoughts on peptide therapeutics, manufacturing, and the greening of peptide science. Fernando and Beatriz are professors at the University of KwaZulu Natal, South Africa. Jon is the VP of Business Development at CEM.
References:
Beatriz G. de la Torre, Shaveer Ramkisson, Fernando Albericio, John Lopez. Refractive Index: The Ultimate Tool for Real-Time Monitoring of Solid-Phase Peptide Synthesis. Greening the Process. Organic Process Research & Development 2021, 25 (4), 1047-1053. DOI: 10.1021/acs.oprd.1c00051
Srinivasa Rao Manne, Omar Luna, Gerardo A. Acosta, Miriam Royo, Ayman El-Faham, Gyorgy Orosz, Beatriz G. de la Torre, and Fernando Albericio. Amide Formation: Choosing the Safer Carbodiimide in Combination with OxymaPure to Avoid HCN Release. Organic Letters 2021 23 (17), 6900-6904. DOI: 10.1021/acs.orglett.1c02466
N-Butylpyrrolidinone as Alternative Solvent for Solid-Phase Peptide Synthesis. John Lopez, Stefan Pletscher, Andreas Aemissegger, Christoph Bucher, and Fabrice Gallou. Organic Process Research & Development 2018 22 (4), 494-503. DOI: 10.1021/acs.oprd.7b00389