HES & EGPA | Expert Webinar 2025: Causes, Symptoms & Treatment Insights

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Understand Hypereosinophilic Syndrome (HES) and Eosinophilic Granulomatosis with Polyangiitis (EGPA): causes, common symptoms, and treatment options for managing these rare conditions. With Prof. Florence Roufosse.

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✅Key Questions and Topics Covered:

02:36 Introducing the Eosinophil: nature and origins, behaviour and functions
11:55 Hypereosinophilia and HES: blood and tissue hypereosinophilia
14:24 HES clinical manifestations
15:18 Pathogenesis of hypereosinophilia in HES: two major disease variants and their disease presentations
20:15 Natural disease course in patients with HES
21:54 HES diagnosis: common causes of increased eosinophil count, evidence of eosinophil-mediated organ damage and dysfunction and disease variants investigations
23:18 EGPA clinical presentation: asthma, blood and tissue hypereosinophilia, vasculitis
25:02 EGPA clinical manifestations: eosinophil-mediated and vasculitic complications
25:50 Typical stepwise EGPA progression
26:28 Overlap between EGPA and HES
26:49 Diagnosis of EGPA: comorbid diseases, blood and pulmonary function tests, ENT check, imaging and other tests.
28:27 Treatment of HES and EGPA: corticosteroid and other treatment options
32:00 Targeting the eosinophil: critical role of Interleukin (IL)-5 in eosinophil biology and as therapeutic targets in eosinophil disorders
34:04 Clinical trials for HES with agents targeting the IL-5 pathway - Mepoluzimab, Benralizumab, tapering corticosteroid doses and outcomes: reduction in blood eosinophil count, fatigue
38:17 How eosinophil-targeted treatments fit in nowadays: tapering corticosteroids, eosinophil-depleting treatments
38:51 Clinical trials for EGPA targeting IL-5: MIRRA trial (Mepoluzimab), MANDARA (Benralizumab) - achieving remission, fewer relapses, reduction in eosinophil counts, and glucocorticosteroids sparing
44:56 Take-home messages