Vielight Masterclass 2 | Alzheimer's Disease and Neurodegeneration Research

Описание: Explore the frontiers of neurodegeneration research in Vielight's Masterclass 2, focusing on the potential of photobiomodulation (PBM) for Alzheimer's Disease and Mild Cognitive Impairment (MCI).

This session delves into the complex science of brain health, investigating the mechanisms by which PBM may support neuronal function.

In this masterclass, you will learn about:
• The Science of PBM: An exploration of how near-infrared light interacts with mitochondria, potentially influencing ATP production, nitric oxide release, and transcription factors.

• Key Physiological Outcomes: A review of preclinical and preliminary research on PBM's potential effects on:
-Blood circulation and angiogenesis
-Neurotrophic (growth) factors like BDNF
-Anti-inflammatory pathways
-Glymphatic flow

• Advanced Brain Imaging: See preliminary data from fMRI and EEG studies (conducted at Baycrest, affiliated with the University of Toronto) showing how different PBM parameters (wavelength, pulse frequency, and delivery method) can influence brain activity, blood flow, and brain wave patterns.

• Microtubule Research: An overview of in vitro studies investigating how different PBM frequencies might interact with tubulin, a key protein related to neurofibrillary tangles.

• MCI Pilot Clinical Trial: A detailed presentation of a pilot randomized clinical trial (RCT) investigating the Vielight Neuro X Gamma device in participants with Mild Cognitive Impairment (MCI). The findings cover:

• Safety and feasibility
• Cognitive outcomes (MMSE, CVLT)
• Blood-based biomarkers (mitochondrial function, IL-6)
• Neuroimaging biomarkers (fMRI, MRS, and structural MRI)

Future Directions: A look at the next phase of research, including a larger, double-blind RCT and the future of personalized PBM applications.

Disclaimer: This video is for informational and educational purposes only. It features discussions on emerging science and preliminary research findings, including pilot studies and in vitro models.

The information presented does not constitute medical advice. Some Vielight products are Health Canada Approved and FDA-registered but beyond that scope are not intended to diagnose, treat, cure, or prevent medical conditions outside that scope. Please consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.

⏱️ YouTube Chapters
(0:00) Introduction (0:13) PBM, Mitochondria, and Alzheimer's Physiology
(0:40) The Mechanism: How NIR Light Activates Mitochondria
(1:15) Key Physiological Outcomes of PBM
(2:21) Why Investigate PBM for Alzheimer's?
(3:42) Potential Advantages: Safety, Home Use, and Cost
(4:32) 🧠 fMRI Study: Measuring the Brain's Real-Time Response (5:59) Comparing Transcranial vs. Intranasal Delivery
(7:28) 🧠 EEG Study: How PBM Influences Brain Waves (Alpha & Gamma)
(9:05) Summary: The Brain Responds Significantly to PBM
(9:17) Microtubule (Tau) Study: Investigating PBM's Effect In Vitro
(10:22) The Critical Role of Pulse Frequency (10 Hz vs. 40 Hz)
(12:47) Summary: Manipulating Parameters for Desired Outcomes
(13:34) Investigating PBM's Effect on Glymphatic Flow
(14:02) A Brief Review of Clinical Studies
(14:56) The Future: Personalized Medicine and AI
(15:16) 🔬 Pilot RCT Presentation: PBM for Mild Cognitive Impairment (MCI)
(15:41) Why Study Mild Cognitive Impairment (MCI)?
(16:04) Targeting Mitochondrial Dysfunction in MCI
(17:33) Study Device: The Vielight Neuro X Gamma
(18:25) Study Design: Pilot Single-Blind RCT Protocol
(20:30) Results: Safety, Adherence, and Adverse Events
(21:05) Results: Cognitive Improvements (CVLT & MMSE)
(21:44) Results: Blood Biomarkers (Mitochondrial & Inflammatory)
(22:58) Results: fMRI (Default Mode Network Connectivity)
(23:32) Results: MRS (Neuronal Viability)
(24:11) Results: Structural MRI (Surprising Changes in Brain Volume)
(25:02) Conclusion: PBM is Safe & Shows Potential for MCI
(25:42) Limitations and Future Research (New Double-Blind RCT)
(26:54) Bonus Research: Dementia & Gulf War Veterans Study

To learn more about photobiomodulation (PBM) in general, please follow the links below:
• https://vielight.com/brain-photobiomo...
• https://www.vielight.com/systemic-pho...
• https://vielight.com/photobiomodulation/

For information on our research, studies and clinical trials, visit:
https://vielight.com/research/

For more information about Vielight photobiomodulation devices, please visit:
https://vielight.com/devices/
https://pro.vielight.com/
https://vielight.com/blog/
https://vielight.com/vielight-e-newsl...