Toxicology (Part-01) Principle of Toxicology with General Terminology | Management of Poisonings

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Toxicology is a scientific discipline, overlapping with biology, chemistry, pharmacology, and medicine, that involves the study of the adverse effects of chemical substances on living organisms and the practice of diagnosing and treating exposures to toxins and toxicants. The relationship between dose and its effects on the exposed organism is of high significance in toxicology. Factors that influence chemical toxicity include the dosage, duration of exposure (whether it is acute or chronic), route of exposure, species, age, sex, and environment. Toxicology is a field of science that helps us understand the harmful effects that chemicals, substances, or situations, can have on people, animals, and the environment. Some refer to toxicology as the “Science of Safety” because as a field it has evolved from a science focused on studying poisons and adverse effects of chemical exposures, to a science devoted to studying safety.

Acute toxicity describes the adverse effects of a substance that result either from a single exposure or from multiple exposures in a short period of time (usually less than 24 hours). To be described as acute toxicity, the adverse effects should occur within 14 days of the administration of the substance.

Subacute toxicity studies are conducted to evaluate a new drug's potential adverse effects following a treatment period of 2–4 weeks' duration. Subacute toxicity studies are conducted as range-finding studies in order to choose dosage levels to be used in subsequent subchronic and chronic toxicity studies.

Chronic toxicity is defined as adverse effects occurring after the repeated or continuous administration of a test sample for a major part of the life span. Harmful effects caused in repeated exposure situations are sometimes called chronic toxicity effects. The following are some examples of chronic toxicity: Inhalation of certain acid vapours at concentrations may, over long periods of time, cause loss of tooth enamel, eventually leading to extensive tooth decay.


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