MDJC19 Structure and function of the hippocampal CA3 module
Автор: Aspirational Neuroscience
Загружено: 2026-02-06
Просмотров: 36
Описание:
Structure and function of the hippocampal CA3 module
R.P. Sammons,M. Vezir,L. Moreno-Velasquez,G. Cano,M. Orlando,M. Sievers,E. Grasso,V.D. Metodieva,R. Kempter,H. Schmidt, & D. Schmitz
Proc. Natl. Acad. Sci. U.S.A. 121 (6) e2312281120. (2024) https://doi.org/10.1073/pnas.2312281120
Presented by Dr. Randal A. Koene
Memory Decoding Journal Club - 2026 session 19
https://aspirationalneuroscience.org
Abstract
The hippocampal formation is crucial for learning and memory, with submodule CA3 thought to be the substrate of pattern completion. However, the underlying synaptic and computational mechanisms of this network are not well understood. Here, we perform circuit reconstruction of a CA3 module using three dimensional (3D) electron microscopy data and combine this with functional connectivity recordings and computational simulations to determine possible CA3 network mechanisms. Direct measurements of connectivity schemes with both physiological measurements and structural 3D EM revealed a high connectivity rate, multi-fold higher than previously assumed. Mathematical modelling indicated that such CA3 networks can robustly generate pattern completion and replay memory sequences. In conclusion, our data demonstrate that the connectivity scheme of the hippocampal submodule is well suited for efficient memory storage and retrieval.
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