#118

Описание: Original release date: 7/6/20

Lloyd Klickstein is the Chief Science Officer at resTORbio, a biopharmaceutical company that develops medications to target the biology of aging. In this episode, Lloyd discusses his company’s clinical application of rapamycin and its derivatives. He also elucidates details of his 2014 paper—a paper that greatly influenced Peter’s perspective of rapamycin in the context of longevity. Peter and Lloyd go on to discuss the dose-dependent effect of rapamycin on immune function and compare rapamycin, fasting, and caloric restriction.

We discuss:
00:00:00 - Intro
00:06:15 - His background and decision to leave academia for translational medicine
00:10:30 - Translational medicine—bridging the gap between basic science and clinical medicine
00:18:00 - What prompted Lloyd to focus on mTOR inhibition?
00:21:30 - Defining mTOR, TORC1, and TORC2, and the consequences of inhibiting them with rapamycin
00:42:15 - Dose-dependent impact of rapamycin on immune function, mTOR inhibition, and toxicity
00:53:00 - Lloyd’s 2014 experiment—mTOR inhibition improves immune function in the elderly
01:13:00 - Insights into autophagy, antigen presentation, and the pleiotropic benefits of a rapalog, and how it compares to fasting
01:18:45 - Lloyd’s 2018 experiment—TORC1 inhibition enhances immune function and reduces infections in the elderly
01:29:00 - Creation of resTORbio, subsequent studies, and takeaways about dosing, TORC2 inhibition, and tissue selectivity
01:40:00 - Comparing the longevity effect of rapamycin, fasting, and caloric restriction
01:47:00 - Excitement around RTB101—resTORbio’s mTOR inhibiting molecule
01:56:15 - Identifying rapalogs selective for TORC1
02:00:00 - Treating depression with ketamine, an activator of mTOR
02:03:30 - Epigenetic clocks, rapalogs, and metformin

Show notes page: https://peterattiamd.com/lloydklickst...

About:
The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 30 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.

Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life).

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