Скачать
Pathogenesis and Therapy of IDH-TET-Mutant Myeloid Malignancies
Автор: The Society for Translational Oncology
Загружено: 2019-01-29
Просмотров: 297
Описание:
Ross L. Levine, MD
Most recently, a series of candidate-gene and whole-genome studies has identified recurrent somatic mutations in AML patients, including TET2, ASXL1, DNMT3A, and EZH2 mutations. Of biological importance, the TET family of proteins has been shown to place a hydroxyl mark on methylated DNA and lead to DNA demethylation. We and others have found that TET2 mutations and IDH1 and IDH2 mutations lead to loss of DNA hydroxymethylation and hypermethylation phenotypes in leukemia patients.
Не удается загрузить Youtube-плеер. Проверьте блокировку Youtube в вашей сети.
Повторяем попытку...
Повторяем попытку...
Доступные форматы для скачивания:
Скачать видео
-
Информация по загрузке:
