Brain Disorder Expert: Tackling Alzheimer's & Other Brain Disorders with LITHIUM

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Check out Woodinville Psychiatric: https://www.woodinvillepsychiatric.com/

Matt and psychiatrist Jon Berner chat about the potential of lithium, a generic drug typically used as a mood stabilizer in illnesses such as bipolar disorder, as an Alzheimer's disease and/or life extension drug. They discuss the data supporting lithium's potential effectiveness in preventing premature dementia, practical considerations and challenges around lithium dose optimization, and possible biological mechanisms that explain lithium's effectiveness. They also delve into the various challenges of studying lithium's effects on humans as well as useful further directions for lithium research.

Jon has been in solo psychiatric practice at Woodinville Psychiatric in Washington since 1997. He spent several years working at the Monroe Correctional Complex, a Washington State Department of Corrections prison. His specialties include brain disorders, particularly bipolar and psychotic illnesses, complex pain, addiction, and "undiagnosed" neuropsychiatric syndromes, and other general psychiatric disorders such as anxiety and depression. Jon has published multiple scientific papers about various topics in the realm of mood disorders and treatments for them. He holds an M.D and a PhD in neuroscience from the University of California, Los Angeles and a B.A. in psychology from Harvard University.

0:00 How Jon bridged the worlds of psychiatry and longevity/rapamycin
2:59 Have the data on lithium and neurodegenerative disease held up over time?
11:01 Why aren't more people talking about lithium for biological aging?
13:12 Are dementia and/or Alzheimer's diseases metabolic diseases?
15:59 Who is likely to benefit from lithium?
29:04 What the Amyloid-Tau-Neurodegeneration (ATN) profile is actually measuring
39:26 Will lithium catch on?
43:21 Lithium dosing
46:23 Why does anyone get a prescription for lithium?
49:49 How much should people taking lithium worry about kidney damage?

Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa

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Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.

On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!