Tachyphylaxis | Introduction of Tachyphylaxis | General Pharmacology | Tolerance Vs Tachyphylaxis

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Tachyphylaxis is a medical term describing an acute, sudden decrease in response to a drug after its administration. i.e. a rapid and short-term onset of drug tolerance. It can occur after an initial dose or after a series of small doses. Increasing the dose of the drug may be able to restore the original response.

Tachyphylaxis is the continued or repeated exposure to a drug that may lead to a weakened pharmacological response. This presumed to be a consequence of diminished receptor sensitivity in response to consistent stimulation by a drug agonist, which produces a diminished pharmacological response in consequence. This is distinct from tolerance. This desensitization process can be a consequence of a decrease in the number of receptors or attenuation of the response because the drug has promoted neurotransmitter release in excess of presynaptic production. The presence of certain enzymes can limit cyclic AMP-based signalling, disrupt second messenger systems, and diminish the availability of receptors at the cell membrane.

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