Reproductive & Gender-Related Drug Therapy | Unit 17 – Pharmacology (12th)

Описание: This unit provides an extensive examination of reproductive and gender-related pharmacology, focusing on the clinical management of patients from preconception through menopause and beyond. It begins with the unique physiological changes of pregnancy, which significantly alter drug pharmacokinetics, and emphasizes the critical role of prenatal supplementation with iron and folic acid to support maternal health and prevent fetal neural tube defects. The text outlines the pharmacological management of common pregnancy discomforts and the high-stakes use of tocolytics, such as magnesium sulfate and terbutaline, to delay preterm labor, alongside antenatal corticosteroids like betamethasone to accelerate fetal lung maturity. During labor and delivery, the focus shifts to pain management through regional anesthesia (epidurals and spinal blocks) and the use of oxytocin for labor induction and the control of postpartum hemorrhage. Neonatal care is addressed via surfactant therapy for premature infants and essential prophylactic treatments for healthy newborns, including phytonadione (vitamin K) and erythromycin ophthalmic ointment.
The unit further explores female reproductive health, detailing the mechanisms, side effects, and delivery systems of combined hormonal contraceptives and progestin-only options, as well as the treatment of gynecological disorders like endometriosis, polycystic ovarian syndrome (PCOS), and dysmenorrhea. It provides guidance on promoting fertility with agents like clomiphene citrate and managing menopause and osteoporosis through hormone therapy and bisphosphonates. Finally, the curriculum covers male reproductive health, focusing on androgen replacement therapy for hypogonadism, treatments for benign prostatic hyperplasia (BPH), and phosphodiesterase-5 inhibitors for erectile dysfunction, concluding with the evidence-based treatment of sexually transmitted infections (STIs).

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