HIV Integrase's Dual Role Uncovered: Breakthrough in Viral Replication and New Drug Targets
Автор: Universal Stories
Загружено: 2025-10-24
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HIV integrase viral replication Salk Institute cryo-electron microscopy RNA binding drug resistance.
Discover the surprising flexibility of HIV integrase, a key protein in HIV-1 replication. Traditional treatments target its DNA integration role, but scientists have now revealed its second function: interacting with viral RNA to spread infection. Using advanced cryo-electron microscopy, researchers from the Salk Institute captured 3D models showing integrase shifting from a 16-part complex for DNA to a 4-part complex for RNA.
This breakthrough, published in Nature Communications, opens doors to new HIV therapeutics that could overcome drug resistance. Explore how these structural changes pave the way for innovative treatments, reducing health issues and stigma for millions living with HIV.
Key insights: HIV evolution, integrase inhibitors, retrovirus mechanisms, and future drug development.
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