NITRIC OXIDE
Автор: Sai Sruthi
Загружено: 2021-06-10
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NITRIC OXIDE
It is one of the oxides of the nitrogen with molecular formula NO indicating that it is a free radical with an unpaired electron.
Nitric oxide is the smallest endogenous signal molecule and the only one which is a gas at normal temperature.
It was proposed by Furchgott & Zwadzki (1980) that on activation by ACh, the endothelial cells released a soluble “endothelium Derived Relaxing Factor” (EDRF). Which diffused to the underlying smooth muscle cell causing relaxation.
A little earlier Farid Murad (1977) have already shown that GTN caused vasodilation by releasing NO.
Ignarro in 1987 confirmed that EDRF in fact was NO.
All three Furchgott, Murad & Ignarro received Nobel prize in 1998 for these discoveries.
NO is the key messenger in the cardiovascular & nervous systems, as well as inflammatory & some other types of cells.
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