Parathyroid hormone (bone resorption) & Calcitonin (bone deposition)

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• Cellular needs for calcium may cause blood calcium concentrations to decline below the normal range.
• This decrease stimulates cells in the parathyroid gland to secrete parathyroid hormone.
• Binding of parathyroid hormone to osteoclasts in bone tissue promotes bone resorption and the release of calcium into the blood.
• As calcium enters the blood, blood calcium concentration is restored to normal levels.

Parathyroid hormone (intestinal calcium absorption, summary)
• Cellular needs for calcium may cause blood calcium concentrations to decline below the normal range.
• This decrease stimulates cells in the parathyroid gland to secrete parathyroid hormone.
• Parathyroid hormone binds to kidney cells promoting their production of calcitriol.
• Calcitriol binds with intestinal cells causing them to increase absorption of calcium.
• As calcium enters the blood, blood calcium concentration is restored to normal levels.
• Increased Parathyroid hormone secretion:
• Promotes bone resorption
• The production of calcitriol
• The result of these actions is an increase in blood calcium levels.

• Nutrient absorption in the small intestine may cause blood calcium concentrations to increase.
• This rise stimulates parafollicular cells in the thyroid gland to secrete calcitonin.
• Calcitonin interacts with osteoblasts in bone tissue and stimulates them to take up calcium from the blood and deposit it in the bone matrix.
• This lowers the blood calcium concentration to normal.