PDE inhibitors for the treatment of erectile dysfunction. WHY??

Описание: In this video, the discussion on why PDE (phosphodiesterase) inhibitors are used in erectile dysfunction.
For penile erection, there is a release of NO (nitric oxide) which is a vasodilator. NO activates guanylyl cyclase to increase cGMP which gets degraded by PDE-5. PDE-5 inhibitor preserves cGMP.

Drugs like sildenafil (viagra) and tadalafil act via this mechanism.

Channel details:
Welcome to my physiology learning channel. I am Dr. Ramkumar S MBBS, MD, DNB physiology. Explain why series will help you to understand concepts in physiology, solve MCQs, answer in Viva, and theory exams. Happy Learning.

#physiology
#explainwhyseries
#PDEinhibitor
#erectiledysfunction
#sildenafil

Suggested book links

For MBBS students
Ganong’s Review of Medical Physiology - https://amzn.to/3GoArCq
Guyton and Hall Textbook of Medical Physiology - https://amzn.to/3LTgwNp

For Postgraduates in Physiology
Berne and Levy Physiology - https://amzn.to/38QDMhi
Boron Physiology - https://amzn.to/38owktL

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