Is this the beginning of the end of lupus? Everything you need to know about CAR-T therapy

Описание: Could CAR-T therapy in lupus mark a new era in autoimmune disease therapy? Join us as we uncover how targeted immune therapy can transform lupus and dive into the benefits and risks of this groundbreaking autoimmune disease therapy.

We’ll also discuss why autoimmunity happens in the first place and how advancements in bioengineering are likely to bring a long lasting remission to those with lupus.

🔗 Links:
CAR-T therapy trials in lupus - https://clinicaltrials.gov/search?con...

Your Appointment Home Run Handbook - https://bit.ly/4heAouK
The guide you need to tell your doc your story -and get answers once and for all!

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3 ways lupus can affect your hands -    • The 3 ways Lupus can affect your hands - a...  

Can we prevent lupus?    • Can we prevent lupus?  

💡Video Key Takeaways
✔️ Autoimmunity occurs when regulatory immune cells fail to control auto-reactive cells, leading to immune attacks on the body. One of the main auto-reactive cells in lupus, are the B cells.
✔️ CAR-T therapy is a cutting-edge treatment that re-engineers a patient’s T cells to target and destroy auto-reactive B cells that produce harmful auto-antibodies.
✔️ While highly targeted, the process involves risks, including infection, inflammation, and significant cost barriers.
✔️ Early results are promising, with severely ill autoimmune patients seeing significant and lasting improvements.
✔️ Key challenges include understanding long-term safety, identifying ideal candidates, and reducing treatment costs.

⏱️Time Stamps:
0:00 Intro
0:47 Autoimmunity 101
4:04 What is CAR-T therapy?
5:38 Current state of CAR-T Therapy
7:29 The future of of CAR-T

📖References:
Rangel-Peláez C, Martínez-Gutiérrez L, Tristán-Manzano M, Callejas JL, Ortego-Centeno N, Martín F, Martín J. CD19 CAR-T cell therapy: a new dawn for autoimmune rheumatic diseases? Front Immunol. 2024 Dec 17;15:1502712. doi: 10.3389/fimmu.2024.1502712. PMID: 39742256; PMCID: PMC11685126.

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👩🏻‍⚕️ About me:
Hello! I am Dr. Elizabeth Ortiz and I’m so happy you are here. I am a double board certified Rheumatologist with over 15 years experience practicing Rheumatology and am passionate about teaching & empowering patients to partner with their doctor.

* The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional. Any comments and/or recommendations made in the comment section by anyone other than Connected Rheumatology does not reflect the opinion or recommendation of Connected Rheumatology.*