Insulin Activated Glucose Uptake. Tyrosine Kinase PI3K/AKT Pathway. GLUT4 Translocation.
Автор: Human Physiology
Загружено: 2024-03-13
Просмотров: 657
Описание:
This lecture starts by introducing the structure of tyrosine kinase receptors. It then discusses how tyrosine kinase receptors have the ability to activate insulin receptor substrate 1 (IRS-1) and how IRS-1 can activate PI3K. Next it discusses how PI3K turns PIP2 into PIP3 and how PIP3 activates PDK1. It finishes by discussing how PDK1 knocks out AS160 which then allows for Rab to become active and GLUT4 translocate.
0:00 Introduction
1:10 Receptor Tyrosine Kinase
5:21 Insulin Receptor Substrate 1 (IRS-1)
8:00 PI3K
9:03 PIP2 to PIP3
10:12 PDK1
11:00 AKT Activation
12:52 GLUT4 and Facilitated Diffusion of Glucose
15:22 AS160 and Rab Activation
18:42 GLUT4 Translocation
21:50 Conclusion
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