Juan Elezgaray - DNA origamis: their folding process and their interactions with lipid membranes
Автор: Erwin Schrödinger International Institute for Mathematics and Physics (ESI)
Загружено: 2025-09-18
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This lecture was part of the Workshop on "Charged Soft Matter: Bridging Theory and Experiment" held at the ESI September 8 - 12, 2025.
DNA nanotechnology dwelves on the self-assembly properties of nucleic acids for the design of molecular devices, including motors and logic circuits. In particular, DNA origamis are the result of an annealing process, where a long single stranded DNA interacts with a set of short DNA sequences, to yield a well defined structure. Despite the maturity of the field, fundamental questions remain open. In this talk, I will address two of them. First, is the result of the folding process unique? Or under which conditions does the annealing process lead to unwanted structures? Second, DNA origamis can be easily modified with hydrophobic moieties to interact with lipid bilayers, The result of this interaction can be a water channel with a well defined structure. I will discuss how this process can be accelerated in the presence of an external (weak) electric field.
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