Element Biosciences: Avidity Sequencing – Accuracy and Applications
Автор: Element Biosciences
Загружено: 2023-02-27
Просмотров: 4487
Описание:
Element VP of Informatics, Semyon Kruglyak, presented a deep dive into the high quality scores of AVITI data and the unique capabilities of Element technology, illustrating how these translate into meaningful advantages for customers. He shared new data showing that AVITI read quality is particularly higher than NovaSeq data in post-homopolymer regions, with potential impacts to variant calling. He also presented internal research on sequencing library inserts greater than 500 bases, enabled by our method of polony generation using rolling circle amplification. Modelled perfect data shows that paired end sequencing of longer inserts provides many of the same advantages as continuous long reads for improved mapping and variant calling. Semyon showed that by sequencing libraries up to 2 kb in length, the AVITI system can provide sufficient coverage in hard to sequence regions of the human genome to enable SNP calling.
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