Do senescent cells promote Alzheimer's pathology or vice versa?

Описание: It is predicted that by 2050 135M people will suffer with Alzheimer's disease. Understanding the development of the disease is therefore of great interest for therapeutics. One idea is to use senolytics - compounds that remove senescent cells. Senescent cells accumulate in the brain during age - are they the cause, contributer or consequence of Alzheimer's disease pathology?

TIMESTAMPS
00:00 - Intro
00:30 - What is Alzheimer's disease?
03:30 - What is cellular senescence?
03:58 - Crosstalk discussion

References (in order of mention)
Saez-Atienzar, S., Masliah, E. Cellular senescence and Alzheimer disease: the egg and the chicken scenario. Nat Rev Neurosci 21, 433–444 (2020). https://doi.org/10.1038/s41583-020-03...
Bussian, T.J., Aziz, A., Meyer, C.F. et al. Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline. Nature 562, 578–582 (2018). https://doi.org/10.1038/s41586-018-05...
Musi, N, Valentine, JM, Sickora, KR, et al. Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell. 2018; 17:e12840. https://doi.org/10.1111/acel.12840
Zhang, P., Kishimoto, Y., Grammatikakis, I. et al. Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model. Nat Neurosci 22, 719–728 (2019). https://doi.org/10.1038/s41593-019-03...

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