DMAE: The next coming of Retin-A? Maybe. But that’s not a good thing.

Описание: In this episode, we apply the AEDUCATOR Evaluation Framework to DMAE (dimethylaminoaethanol).

Hailed by one YouTube skincare enthusiast as “best thing since Retin-A,” the evaluation of DMAE reveals a lot of what is wrong with skincare today.
First, we see a doctor who “discovered” DMAE by cluelessly applying it to the face of a patient – it caused the face to become lopsided in 20 minutes. Based on this experience, the doctor develops a completely unsupported theory involving neurotransmitters and muscle change. He does “independent” clinical studies that are never published.

We see Johnson and Johnson seize on this opportunity. They conduct 2 clinical studies that are never published (positive results) and sponsor an academic lab to do 2 others (negative results). Ultimately, they drop the idea of DMAE as a “breakthrough” ingredient. To my knowledge DMAE is not used in any products made by J&J companies, but there are so many of these, it’s hard to know.

Then, we see two YouTube skincare channels grapple with this legacy. One – Mad About Skin – jumps in head first. It’s the BEST, he shouts. Better than Retin-A. In fewer than 10 minutes, the covers the ingredient, how it works, all the data, and how to integrate into a routine. The other YouTube channel – No BS Beauty – is much more circumspect. “This is controversial. Read the research yourself. Decide for yourself if you want to be a guinea pig.”

This is where AEDUCATOR comes in. We take a comprehensive look at DMAE through the lens of the AEDUCATOR Framework – The What, The How, The Evidence, The Sources. We discuss the peer-reviewed research critically. Pointing out the nuance that determines whether something is solid or fluff.

These are the papers referred to in this video. If you have trouble getting them, please message us and we can send you.
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Canadian In-Vitro and Pre-Clinical Study
The antiwrinkle effect of topical concentrated 2-dimethylaminoethanol involves a vacuolar cytopathology - PubMed (nih.gov)
https://pubmed.ncbi.nlm.nih.gov/17300...
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Brazil Pre-Clinical and Clinical Study.
In vivo skin effects of a dimethylaminoethanol (DMAE) based formulation
PubMed (nih.gov)
https://pubmed.ncbi.nlm.nih.gov/20095...
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Belgian Study.
Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel - PubMed (nih.gov)
https://pubmed.ncbi.nlm.nih.gov/12236...
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Review of DMAE including mention of 2 Johnson & Johnson clinical studies. The role of dimethylaminoethanol in cosmetic dermatology - PubMed (nih.gov)
https://pubmed.ncbi.nlm.nih.gov/15675...

Timestamps:
0:00 Introducing DMAE: Why we had to evaluate it first (hint: it tells us a lot about the skincare industry).
03:15 DMAE through the prism of YouTube: A doctor and 2 enthusiasts give THE WHAT.
12:06 THE HOW or MECHANISM OF ACTION as suggested by YOUTUBE.
16:26 Evaluating THE MECHANISMS OF ACTION with IN VITRO DATA.
26:44 We get lucky. There is IN VIVO data.
33:00 The clinical studies. Lots of studies.
49:58 Data sources. The good and the bad.
52:39 The AEDUCATOR conclusion.