Platelets in Physiology: Structure, Formation and Role in Hemostasis and Blood Clotting
Автор: PHARMA TECHNOLOGY
Загружено: 2026-02-22
Просмотров: 13
Описание:
Platelets, also known as thrombocytes, are small, non-nucleated cell fragments derived from megakaryocytes in the bone marrow. They play a crucial role in hemostasis, which is the process that prevents blood loss after vascular injury. The normal platelet count ranges from 150,000–400,000/µL of blood.
Structurally, platelets contain granules (alpha and dense granules) that store important substances such as clotting factors, serotonin, calcium, and platelet-derived growth factor (PDGF). When a blood vessel is injured, platelets adhere to the damaged endothelium, become activated, and aggregate to form a temporary platelet plug.
Their major functions include:
Primary hemostasis (formation of platelet plug)
Activation of coagulation cascade
Release of clotting factors and vasoconstrictors
Wound healing and tissue repair
Maintenance of vascular integrity
Abnormalities in platelet number or function can lead to bleeding disorders (thrombocytopenia) or excessive clot formation (thrombocytosis).
#Platelets #Thrombocytes #Physiology #Hemostasis #BloodClotting #Coagulation #Megakaryocytes #Hematology #PlateletPlug #WoundHealing
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