Advancing Glaucoma Monitoring: Inner Plexiform Layer Microstructure in Focus
Автор: Eye Care Network | Ophthalmology & Optometry
Загружено: 2026-03-12
Просмотров: 24
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In late 2025, a group of researchers that included Maria Emfietzoglou, MD, and Victor S.M.C. Correa, MD, published a paper titled, “Inner Plexiform Layer Substrata Are Discernible with Commercial OCT and Affected by Aging,” in Ophthalmology Sciences, which suggested that analysis of the inner plexiform layer (IPL) and its sublayers via commercial OCT is both feasible and reproducible, and that the IPL microstructure changes with aging.
Emfietzoglou, a research fellow in ophthalmology at Massachusetts Eye and Ear, and Correa, an ophthalmology resident at the University of Missouri-Kansas City, came together with Ophthalmology Times to discuss their work, which is particularly timely as we recognize World Glaucoma Day.
Although much of glaucoma monitoring has traditionally focused on retinal nerve fiber layer (RNFL) and ganglion cell layer thickness, growing evidence suggests that synaptic and dendritic changes may precede overt neuronal loss. The IPL—a synapse-rich region where bipolar, amacrine, and ganglion cell connections converge—represents a potential window into earlier microstructural dysfunction. This study highlights a more nuanced way of assessing inner retinal health and potentially raises questions about whether advanced IPL analysis could enhance early detection, risk stratification, and longitudinal monitoring of disease progression beyond thickness metrics alone.
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