Paper Discussion 11 | NEET MDS 2019

Описание: 1. Dantrolene sodium is used.

"Immediately begin dantrolene sodium 2.5 mg/kg. Rapidly administer the initial bolus intravenously with supplemental increments up to 10mg/kg. A central venous line is preferred in order to avoid peripheral venous thrombosis. Each vial of dantrolene contains 20 mg dantrolene and 3 g mannitol. One vial should be mixed with 60 mL of sterile water for injection (USP). Continue to administer dantrolene until signs of MH (e.g. hypercarbia, rigidity, tachycardia and fever) are controlled. Occasionally more than 10 mg/kg dantrolene total dose may be needed, but clinical reassessment is suggested."

"Cardiac arrhythmias are often reversible after administration of dantrolene. However, in some cases, administration of amiodarone or beta-blockers is indicated to treat persistent tachyarrhythmia. Administration of calcium antagonists is contraindicated, because severe episodes of hyperkalemia have been reported in the context of dantrolene treatment. Hyperthermia should be treated by internal cooling with cold infusion fluids and external surface cooling with ice packs placed in the axillae and groin or specific cooling devices until body temperature reaches 38.5°C."

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