How is Agomelatine different from other Antidepressants? | A Psychiatrist Explains | Dr Rege
Автор: Dr. Rege
Загружено: 2022-04-10
Просмотров: 32279
Описание:
Agomelatine, also known as Valdoxan, is a novel and atypical antidepressant that acts as a melatonergic antidepressant and has a distinctly favourable side effect profile. Dr Sanil Rege, Consultant Psychiatrist, explains its mechanism of action.
#agomelatine #valdoxan #antidepressants
Agomelatine is a melatonin receptor agonist (M1 & M2) and a serotonin 5 HT2C receptor antagonist with a favourable side effect profile. There is a lack of sexual dysfunction, sleep benefits, and no discontinuation symptoms – all of which confer valuable clinical benefits in the treatment of depression.
Hyperactivity of the 5-HT2C receptors may contribute to the symptoms of MDD, and agomelatine-induced 5-HT2C antagonism has been shown to increase the release of dopamine and norepinephrine in the frontal cortex.
Agomelatine is evidence-based in the treatment of depression, anxiety, OCD and bipolar depression.
Read more on agomelatine: https://psychscenehub.com/psychinsigh...
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