Genomic Health of Ancient Hominins: DNA Analysis (Berens et al., 2017)

Описание: I. Introduction to Ancient Genomic Health
Ancient DNA reveals disease risks in past populations.
Researchers analyzed 147 ancient genomes for health data.
They used genetic risk scores to measure disease burden.
This method helps diagnose health without soft tissue.
It estimates hereditary disease risks across time periods.
The study combines ancient DNA with modern disease data .

II. Comparison with Modern Humans
Ancient disease risks are similar to modern humans.
Risk scores span the full range of present day people.
Some ancient genomes are among the healthiest known .
Others fall into the least healthy categories .
Ancient samples often show lower risk for cancer .
They also show lower risk for neurological issues .
Cardiovascular risk was higher in ancient hominins .
Immune disease risk was not significantly different .

III. Trends Over Time & Space
Genomes from the recent past appear healthier.
Oldest samples showed much greater genetic risk .
Health improved significantly over thousands of years .
Northern individuals tended to be healthier .
This trend follows a North South geographic cline .
Latitude correlates with lower cancer risk .
Eastern individuals had lower heart disease risk .

IV. Impact Of Lifestyle On Health
Subsistence mode affects estimated genetic disease risk .
Ancient pastoralists had the healthiest genomes.
They scored lower risk than hunter gatherers .
Agriculturalists had higher dental disease risk .
Hunter gatherers had higher immune disease risk .
Diet shifts likely influenced genetic health evolution .
Pastoralists showed low risk for gastrointestinal issues .

V. Case Studies of Specific Individuals
The Altai Neandertal had poor genomic health.
Its risk score was worse than 97 percent of humans.
It had high risk for immune and liver diseases .
Otzi the Iceman had a heart disease predisposition.
He also carried high risk for gastrointestinal issues .
Otzi had relatively healthy scores for other traits .
Neandertal DNA links to depression risk in moderns .

VI. Additional Resource Support
See NourishED RFI's NotebookLM Resource Support Page.
https://notebooklm.google.com/noteboo...

VII. Source
Berens, A. J., Cooper, T. L., & Lachance, J. (2017). The genomic health of ancient hominins. School of Biological Sciences, Georgia Institute of Technology.

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